Weight-loss surgery likely to reduce genetic risk for developing breast cancer


breast cancer

Journal “ObesityWeek” recently published a study conducted on women with a genetic predisposition for breast cancer. The study found out that women who have a genetic predisposition for breast cancer are 2.5 times more likely to develop a malignancy compared to the women with the same genetic risk but have gone through bariatric or weight loss surgery.

The study showed that women with severe obesity or body mass index (BMI) of 35 or higher had an 18 percent chance of breast cancer which closely matched women who underwent weight-loss surgery had just 7.4 percent chances of breast cancer. The study also concluded that weight-loss surgery can cut the overall risk of breast cancer by 20 percent.

During the study, researchers reviewed the data of 1,670,035 patients with a BMI of 35 or higher collected during 2010 to 2014 in National Inpatient Sample (NIS), the largest of all players in patient healthcare database. Researcher compared the data about breast cancer incidence of 1.4 million patients who did not undergo bariatric surgery to 250,000 patients who did undergo weight-loss surgery.

Emanuele Lo Menzo, Associate Program Director and General Surgery Residency Program, co-author of the study said that the findings of the study suggests that bariatric surgery could significantly prevent the development of cancer in patients with a higher risk than the average population, even in genetically predisposed.

Menzo also added,” The effects of weight-loss surgery on patients genetically predisposed to development of breast cancer were remarkable and we believe this is the first time a study has shown such an impact”. Munzo further said that there is a need of further studies to understand and determine the factors that may lead to such reduction in risk of breast cancer.

ACS, American Cancer Society, suggests that having more tissue can increase the chances of breast cancer by increased estrogen level. According to the U.S. Centers for Disease Control and Prevention (CDC), overweight and obesity are associated with an increase in risk of 13 types of cancer, which accounted for 40 percent of all cancers diagnosed in the United States in 2014.

The American Society of Clinical Oncology (ASCO) points out obesity as a significant but unrecognized risk factor for breast cancer, and it has also been associated with an increased risk of recurrence of cancer and mortality rate in patients with breast cancer.

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